For the moment, there are two brands with this competition on the market: ZUIDEX (Q-med, Sweden) and URODEX (BioPolymer, Germany)

URODEX has the advantage, that its dextranomer particles have a positive charge: This effects a much better collagen synthesis than uncharged particles due to increased phagozyte attraction. This effect is known from aesthetic medicine (correction of folds and wrinkles) and proven by ultrasound investigations (Kollagenoson).

Besides that, URODEX has an enormous economical advantage, its price is far below Zuidex.

Both substances were also used for the correction of the vesico- ureteral reflux in children.

The presented papers show the results of the submucosal injection with Dextranomere/Hyaluronic acid copolymer for the minimal invasive treatment of SUI. They are representative for many reports about the success with the new promising material.

These are as follows:

An open, multicenter study of NASHA/Dx Gel for the treatment of stress urinary incontinence

(NASHA= non animal derived stabilized hayluronic acid; dx= dextranomere Chappie et al., UK 2005

Satisfying results after 12 months ,( n= 142, average age 55,7 ) in 77%.

Reduction of urinary loss in 24h pad test reduced for 89% (average) in comparison to baseline investigation.

The summary is as follows:

“Treatment with NASHA/Dx gel produced large, statistically significant reductions in urinary leakage sustained over 12 months and was well tolerated. These findings suggest that the NASHA/Dx gel could be considered as early intervention in treatment cases of SUI.”

Urethral injection for SUI: long term results with dextranomere/hyaluronic acid copolymer

Stenberg et al, Sweden 2003

Long time results from patients since 1994/95 Average age 67, n=20, 16 completed Only in 3 cases (15%) not satisfying result.

The urethral injection of the copolymer is an effective solution concerning long time results in SUI treatment, regardless age or other treatments before.

Zuidex treatment of SUI-impact on quality of life Farrelly et al, Sweden

42 patients were asKed about their improvement of quality of life after the treatment. The result was the same after 3 and 12 months (70% improvement), thus, the result remained stable.

Langzeitergebnisse nach urethraler Injektion bei Belastungsharninkontinenz Stenberg, Sweden 2003

16 patients completed, 57% cure or improvement even after 7 years!

The results show, that the treatment of the SUI with the gel is an effective and very low risk alternative to surgery and TVT for many cases.

The advantages for the patients are clear: No hospitalization, can be done as outpatient procedure, no general anesthesia required, pregnancy possible after treatment, also retreatment possible at any time, as well as other treatment options, if required.

URODEX offers also an enormous economical advantage, if costs for incontinence aids and/or hospitalization are considered.

  1.  Minimal invasive
  2.  No hospitalization required, can be done as outpatient procedure
  3.  No General anaesthesia required
  4.  No rehabilitation time after treatment
  5.  Minimal Risk for Complications
  6.  Pregnancy possible after treatment
  7.  No risk for life- threatening complications
  8.  Easy to learn, easy administration
  9.  Big economical advantages

42 patients were asked about their improvement of quality of life after the treatment. The result was the same after 3 and 12 months (70% improvement), thus, the result remained stable.

Langzeitergebnisse nach urethraler Injektion bei Belastungsharninkontinenz Stenberg, Sweden 2003

16 patients completed, 57% cure or improvement even after 7 years!

The results show, that the treatment of the SUI with the gel is an effective and very low risk alternative to surgery and TVT for many cases.

The advantages for the patients are clear: No hospitalization, can be done as outpatient procedure, no general anesthesia required, pregnancy possible after treatment, also retreatment possible at any time, as well as other treatment options, if required.

URODEX offers also an enormous economical advantage, if costs for incontinence aids and/or hospitalization are considered.

  1. Minimal invasive
  2. No hospitalization required, can be done as outpatient procedure
  3. No General anaesthesia required
  4. No rehabilitation time after treatment
  5. Minimal Risk for Complications
  6. Pregnancy possible after treatment
  7. No risk for life- threatening complications
  8. Easy to learn, easy administration
  9. Big economical advantages